Arbeidsområder
- Åpen forskning og forskningsdatahåndtering
- Forskningsetikk og personvern
- Forskningsledelse og prosjektledelse
- Karriereutvikling
Bakgrunn
- Forskningsrådgiver/prosjektkoordinator, Forskningsavdelingen Kreftregisteret
- Førstekonsulent, Statistisk sentralbyrå
- Master i sosiologi, Universitetet i Oslo
Emneord:
Datahåndtering,
Prosjektledelse,
Cristin,
Personvern,
Forskningsstøtte,
Kompetanseutvikling,
Forskningsetikk
Publikasjoner
-
Bucher-Johannessen, Cecilie; Birkeland, Einar Elvbakken; Vinberg, Elina; Bemanian, Vahid; Hoff, Geir Svein & Berstad, Paula
[Vis alle 7 forfattere av denne artikkelen]
(2023).
Long-term follow-up of colorectal cancer screening attendees identifies differences in Phascolarctobacterium spp. using 16S rRNA and metagenome sequencing.
Frontiers in Oncology.
ISSN 2234-943X.
13.
doi:
10.3389/fonc.2023.1183039.
Fulltekst i vitenarkiv
Vis sammendrag
Background: The microbiome has been implicated in the initiation and progression of colorectal cancer (CRC) in cross-sectional studies. However, there is a lack of studies using prospectively collected samples.
Methods: From the Norwegian Colorectal Cancer Prevention (NORCCAP) trial, we analyzed 144 archived fecal samples from participants who were diagnosed with CRC or high-risk adenoma (HRA) at screening and from participants who remained cancer-free during 17 years of follow-up. We performed 16S rRNA sequencing of all the samples and metagenome sequencing on a subset of 47 samples. Differences in taxonomy and gene content between outcome groups were assessed for alpha and beta diversity and differential abundance.
Results: Diversity and composition analyses showed no significant differences between CRC, HRA, and healthy controls. Phascolarctobacterium succinatutens was more abundant in CRC compared with healthy controls in both the 16S and metagenome data. The abundance of Bifidobacterium and Lachnospiraceae spp. was associated with time to CRC diagnosis.
Conclusion: Using a longitudinal study design, we identified three taxa as being potentially associated with CRC. These should be the focus of further studies of microbial changes occurring prior to CRC diagnosis.
-
Kværner, Ane Sørlie; Birkeland, Einar Elvbakken; Vinberg, Elina; Hoff, Geir; Hjartåker, Anette & Rounge, Trine Ballestad
[Vis alle 7 forfattere av denne artikkelen]
(2022).
Associations of red and processed meat intake with screen-detected colorectal lesions.
British Journal of Nutrition.
ISSN 0007-1145.
s. 1–36.
doi:
10.1017/S0007114522002860.
Fulltekst i vitenarkiv
Vis sammendrag
Limited data exist regarding the role of meat consumption in early-stage colorectal carcinogenesis. We examined associations of red and processed meat intake with screen-detected colorectal lesions in immunochemical fecal occult blood test (FIT)-positive participants, enrolled in the Norwegian CRCbiome study during 2017-2021, aged 55-77 years. Absolute and energy-adjusted intakes of red and processed meat (combined and individually) were assessed using a validated, semiquantitative food frequency questionnaire. Associations between meat intake and screen-detected colorectal lesions were examined using multinomial logistic regression analyses with adjustment for key covariates. Of 1,162 participants with available dietary data, 319 (27%) presented with advanced colorectal lesions at colonoscopy. High vs low energy-adjusted intakes of red and processed meat combined, as well as red meat alone, were borderline to significantly positively associated with advanced colorectal lesions (ORs (95% CIs) of 1.24 (0.98, 1.57) and 1.34 (1.07, 1.69), respectively). A significant dose-response-relationship was also observed for absolute intake levels (OR (95% CI) of 1.32 (1.09, 1.60) per 100 g/day increase in red and processed meat). For processed meat, no association was observed between energy-adjusted intakes and advanced colorectal lesions. A significant positive association was, however, observed for the small proportion of participants (10%) with absolute intake levels ≥100 vs <50 g/day (OR (95% CI) of 1.19 (1.09, 1.31)). In summary, high intakes of red and processed meat were associated with presence of advanced colorectal lesions at colonoscopy in FIT-positive participants. The study demonstrates a potential role of using dietary data to improve the performance of FIT-based screening.
-
-
Larsen, Inger Kristin; Myklebust, Tor Åge; Babigumira, Ronnie; Vinberg, Elina; Møller, Bjørn & Ursin, Giske
(2020).
Education, income and risk of cancer: results from a Norwegian registry-based study.
Acta Oncologica.
ISSN 0284-186X.
59(11),
s. 1300–1307.
doi:
10.1080/0284186X.2020.1817548.
-
Hart, Rannveig Kaldager; Lyngstad, Torkild Hovde & Vinberg, Elina
(2017).
Children and Union Dissolution across Four Decades: Evidence from Norway.
European Sociological Review.
ISSN 0266-7215.
33(2),
s. 317–331.
doi:
10.1093/esr/jcx039.
Se alle arbeider i Cristin
Publisert
6. jan. 2022 18:19
- Sist endret
29. nov. 2023 15:29